Ultrasensitive non-enzymatic uric acid electrochemical sensor based on Silicon nanowires (SiNWs) modified screen-printed carbon electrode (SPCE)

A non-enzymatic electrochemical sensor using a disposable Screen Printed Carbon electrode (SPCE) modified with SiNWs was developed for the determination of uric acid (CIA). The surface morphology of SiNWs-modified SPGE was observed by Field Emission Scanning Electron Microscopy (FESEM) and its electrochemical behavior was investigated by cyclic voltammetry (CV) and different pulse voltammetry (DPV). The SPGE modified with SiNWs showed a good electrocatalytic activity towards uric acid compared with the unmodified SPCE. Under optimal condition, the developed electrochemical enzyme exhibited a wide linear range for determination of IJA ranging from 100 PM to 0.1 nM with detection limits of 3.5 nM (S/N=3). In addition, the SiNWs-modified SPGE also had good selectivity and stability.